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People who have undergone bariatric surgery before starting semaglutide also need close monitoring

Moreover, hydrochlorothiazide have been shown to diminish insulin secretion from islets of obese mice by reducing Ca 2+ influx rather than altering [Cl ] i , K + or Cl fluxes (Sandstrom et al., 1993)

Dysregulated mTORC1 and TFEB signaling exacerbate these autophagic defects, prompting research into the use of autophagy modulators as potential therapeutic strategies [144, 146]